Contraindicated (1)pentobarbital will reduce the level or outcome of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Energetic metabolites.pentobarbital will lessen the level or effect of repaglinide by impacting hepatic/intestinal enzyme CYP3